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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T63360 | DNA topoisomerase II inhibitor 1 | ||
DNA topoisomerase II inhibitor 1 is a potent inhibitor of DNA topoisomerase II that arrests the cell cycle in sub-G1 phase and induces apoptosis with anti-value-added effects. | |||
T36968 | ARN-21934 | Topoisomerase | |
ARN-21934 is a potent, highly selective, blood-brain barrier (BBB) penetrant inhibitor for human topoisomerase II α over β. ARN-21934 inhibits DNA relaxation with an IC50 of 2 μM as compared to the anticancer agent Etopo... | |||
T61054 | Type II topoisomerase inhibitor 1 | ||
Type II topoisomerase inhibitor 1 is able to be used in the antibacterial area. Type II topoisomerase inhibitor 1 is a potent and selective inhibitor of E. coli DNA gyrase with a IC50 value of 1.7 nM as well as forms hyd... | |||
T61017 | Topoisomerase II inhibitor 6 | ||
Topoisomerase II inhibitor 6 (Compound 5) is a tryptanthrin derivative. Topoisomerase II inhibitor 6 is a potent and selective topoisomerase II inhibitor. Topoisomerase II inhibitor 6 blocks the CCRF-CEM cell cycle in th... | |||
T61283 | Topoisomerase II inhibitor 3 | ||
Topoisomerase II inhibitor 3 (Compound 6 h) is an acridone derivative that acts as a Type II DNA topoisomerase (topo II) inhibitor. It specifically inhibits the topo IIα/β subtypes, with an IC50 value of 0.17 μM for topo... | |||
T18317 | MCC-Modified Daunorubicinol | Others | |
Daunorubicinol, a potent antitumor drug-linker conjugate for antibody-drug conjugate (ADC) applications, utilizes Aur0101 (DNA Topoisomerase II inhibitor) connected through the ADC linker[1]. | |||
T61045 | Topoisomerase I/II inhibitor 2 | ||
Topoisomerase I/II inhibitor 2 (compound 1a) can significantly reduce the xenograft tumor growth in mice model which can be used in treating liver cancer. Topoisomerase I/II inhibitor 2 is a DNA topoisomerase I/II dual i... | |||
T61351 | Pixantrone hydrochloride | ||
Pixantrone (BBR 2778 (free base)) hydrochloride is a mitoxantrone analog compound that acts as a topoisomerase II inhibitor and DNA intercalator. It displays anti-tumor activity [1] [2]. | |||
T79539 | Topoisomerase II inhibitor 16 | Topoisomerase | |
Topoisomerase II Inhibitor 16 (compound CT3) is a selective, orally bioavailable, and irreversible inhibitor of trypanosomal topoisomerase II, possessing the ability to penetrate the brain and stabilize double-stranded D... | |||
T81745 | MSN8C | ||
MSN8C, a mansonone E analog, acts as a novel catalytic inhibitor of human DNA topoisomerase II, inducing apoptosis in cancer cells and exhibiting considerable anti-tumor cell proliferation activity in vitro [1]. | |||
T61481 | TP0480066 | ||
TP0480066, a selective topoisomerase II inhibitor, demonstrates excellent inhibitory activity against DNA gyrase (IC50 = 1.10 nM) and topo IV (IC50 = 62.89 nM). This compound exhibits potent efficacy against multiple bac... | |||
T61431 | Topoisomerase IIα-IN-4 | ||
Topoisomerase IIα-IN-4 (F2) is a non-intercalative ATP-competitive inhibitor of human DNA topoisomerase II, specifically inhibiting TopoIIα with an IC50 value of 3.8 μM and TopoIIβ with an IC50 value of 10.1 μM. It demon... | |||
T36695 | TAS-103 | ||
TAS-103 is a dual inhibitor of DNA topoisomerase I/II, used for cancer research. TAS-103 is a dual inhibitor of DNA topoisomerase I/II. TAS-103 (0.1-10 μM) is active on CCRF-CEM cells, with an IC50 value of 5 nM. TAS-103... | |||
T73700 | Daunorubicin citrate | ||
Daunorubicin (Daunomycin) citrate, a potent anti-tumor anthracycline antibiotic, acts as a topoisomerase II inhibitor. It effectively inhibits DNA and RNA synthesis, diminishes cancer cell viability, and promotes apoptos... | |||
T75303 | Suramin | ||
Suramin is a reversible, competitive inhibitor of protein-tyrosine phosphatases (PTPases) [1], demonstrating potent inhibition against sirtuins: SirT1 (IC50=297 nM), SirT2 (IC50=1.15 μM), and SirT5 (IC50=22 μM) [2]. It a... | |||
T36199 | AZD 1152 (hydrochloride) | ||
AZD 1152 is an orally bioavailable prodrug of AZD 1152-HQPA, a selective inhibitor of Aurora kinase B (IC50= 0.36 nM).1AZD 1152 is converted to AZD 1152-HQPA in plasma. Inhibition of Aurora B results in disruption of spi... |